My research interests focus on the study of the molecular and neurophysiological mechanisms of primary headache and facial pain disorders in a translational approach across experimental and clinical settings.

To date, I have authored numerous papers on headache disorders including several book chapters and treatment guidelines.

I am an associate editor for the Journal of Headache and Pain. I am Co-Deputy Lead of the Pain and Addictions Theme at the NIHR Maudsley Biomedical Research Centre.

Please see my Research Staff Profile for more details.

Key publications:

• Ornello et al., 2025. Evidence-based guidelines for the pharmacological treatment of migraine. Cephalagia
• Hoffmann et al., 2025. Kinetic Oscillation Simulation for the Preventive Treatment of Chronic Migraine: A Randomized, Double-Blind, Sham-Controlled Trial. Neurology.
• Ashina et al., 2024. Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine. Nature Reviews Neurology.
• Gordon et al., 2023. Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review. Journal of Neurology, Neurosurgery, and Psychiatry. 
• Hoffmann et al., 2020. PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? Pain.

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Key collaborators:

• Professor Peter J. Goadsby, King’s College London
• Professor Rigmor Jensen, University of Copenhagen
• Professor Arne May, University Medical Center Hamburg-Eppendorf
• Professor Messoud Ashina, University of Copenhagen